Professor Zhang’s research has centred on the aetiology, pathogenesis, and treatment of kidney diseases within the framework of traditional Chinese medicine. During the 1980s, he edited Practical TCM Nephrology and the Dictionary of TCM Nephrology, contributing to the systematic development and standardisation of TCM nephrology as a distinct clinical field. He proposed theoretical approaches including the Heart–Kidney Axis and kidney deficiency complicated by blood stasis, and developed therapeutic approaches combining kidney-tonifying and blood-activating methods. His clinical and experimental research has examined the application of TCM in glomerular sclerosis, renal interstitial fibrosis, tubular atrophy, chronic nephritis, chronic renal failure, and diabetic nephropathy, and has contributed to the development of more than 20 proprietary preparations used in clinical practice. He has led national research projects under several Five-Year Plan programmes and has published more than 100 research papers and over 10 monographs, several of which have been translated and published internationally. He has also supervised more than 60 apprentices and established clinical training and mentorship programmes in hospitals across China. Through sustained research, clinical practice, and medical education, Professor Zhang has contributed to the theoretical development of TCM nephrology, its integration with contemporary clinical research, and the training of specialists in the prevention and treatment of kidney disease.