Professor Chang’s scientific research has centred on respiratory physiology and the application of engineering methods to biomedical and clinical problems, contributing to the development of biomedical engineering as an interdisciplinary field. During his academic career in North America, he published more than 100 scientific papers and contributed to the development of biomedical engineering education and research programmes, training professionals at the interface of engineering, medicine, and physiology. His academic leadership subsequently extended to institution building in Hong Kong, where he played a role in establishing and developing engineering education at the Hong Kong University of Science and Technology and in shaping the development of City University of Hong Kong. In his later career, Professor Chang has devoted considerable attention to general education and the humanities. He has taught courses on history, culture, and world civilisations at universities in China and abroad, and has published 12 books in Chinese and English, including Journey through the Greater Middle East, Reflections on the Nile, Cultivation in University: Thirty-Six Lectures on the Humanities, and Tea and Coffee: Lectures on Culture and Economics. His writing and teaching explore the relationship between technological development, higher education, cultural understanding, and the humanities. Through research in biomedical engineering, university leadership, and sustained engagement with humanistic education and cross-cultural dialogue, Professor Chang has contributed to the development of biomedical engineering and higher education in Hong Kong and internationally.